| 1. Round | 24/07/2021 | Lokomotiv Moskva [Youth] | - | FK Strogino Moskva [Youth] | 2:1 | ||||
| 3. Round | 07/08/2021 | Lokomotiv Moskva [Youth] | - | FK Rostov [Youth] | 0:1 | ||||
| 4. Round | 14/08/2021 | SShOR Zenit [Youth] | - | Lokomotiv Moskva [Youth] | 4:1 | ||||
| 5. Round | 21/08/2021 | Rubin Kazan [Youth] | - | Lokomotiv Moskva [Youth] | 1:2 | ||||
| 7. Round | 13/09/2021 | Lokomotiv Moskva [Youth] | - | Zenit St. Petersburg [Youth] | 2:3 | ||||
| 8. Round | 18/09/2021 | FK Krasnodar [Youth] | - | Lokomotiv Moskva [Youth] | 3:1 | ||||
| 11. Round | 16/10/2021 | Lokomotiv Moskva [Youth] | - | Dinamo Moskva [Youth] | 4:1 | ||||
| 12. Round | 23/10/2021 | Lokomotiv Moskva [Youth] | - | Kuban Krasnodar [Youth] | 2:2 |
Russia