| 20. Round | 06/03/2022 | FK Biolog Novokubansk | - | FK Mashuk KMV | 2:1 | ||||
| 22. Round | 19/03/2022 | FK Biolog Novokubansk | - | FK Chayka | 1:1 | ||||
| 23. Round | 28/03/2022 | Anzhi Makhachkala | - | FK Biolog Novokubansk | 1:1 |  |
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| 24. Round | 03/04/2022 | FK Biolog Novokubansk | - | FK Druzhba | 0:0 | ||||
| 21. Round | 06/04/2022 | Spartak Nalchik | - | FK Biolog Novokubansk | 0:1 |  |
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| 25. Round | 10/04/2022 | Alania-2 Vladikavkaz | - | FK Biolog Novokubansk | 1:4 | |
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| 26. Round | 17/04/2022 | FK Biolog Novokubansk | - | Kuban-Holding Pavlovskaya | 2:5 | |
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| 27. Round | 23/04/2022 | Forte Taganrog | - | FK Biolog Novokubansk | 2:2 | ||||
| 28. Round | 30/04/2022 | FK Biolog Novokubansk | - | FK Dinamo Makhachkala | 0:4 | ||||
| 29. Round | 06/05/2022 | Rotor-2 Volgograd | - | FK Biolog Novokubansk | 1:3 | |
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| 30. Round | 12/05/2022 | FK Biolog Novokubansk | - | FK Tuapse | 1:0 | ||||
| 31. Round | 16/05/2022 | FK SKA Rostov | - | FK Biolog Novokubansk | 2:2 | |
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| 32. Round | 22/05/2022 | FK Biolog Novokubansk | - | Dinamo Stavropol | 3:3 | |
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| 34. Round | 05/06/2022 | FK Biolog Novokubansk | - | FK Yessentuki | 3:1 | |
Russia