| 2. Round | 20/08/2005 | FC Twente | - | NEC Nijmegen | 0:1 | ||||
| 3. Round | 28/08/2005 | FC Utrecht | - | FC Twente | 1:3 | ||||
| 4. Round | 11/09/2005 | FC Twente | - | Vitesse | 0:1 | ||||
| 5. Round | 16/09/2005 | ADO Den Haag | - | FC Twente | 0:0 | ||||
| 6. Round | 25/09/2005 | FC Twente | - | Feyenoord | 1:3 | ||||
| 8. Round | 15/10/2005 | FC Twente | - | RKC Waalwijk | 2:0 | ||||
| 9. Round | 22/10/2005 | NAC Breda | - | FC Twente | 1:1 | ||||
| 10. Round | 29/10/2005 | FC Twente | - | PSV Eindhoven | 0:1 | ||||
| 11. Round | 05/11/2005 | FC Twente | - | Willem II | 3:1 | ||||
| 15. Round | 10/12/2005 | FC Twente | - | AZ Alkmaar | 1:3 | ||||
| 19. Round | 15/01/2006 | Willem II | - | FC Twente | 1:1 | ||||
| 20. Round | 22/01/2006 | FC Twente | - | AFC Ajax | 2:3 |
Russia