| 4. Round | 31/07/2021 | FK Neftekhimik | - | Metallurg Lipetsk | 5:0 |  |
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| 8. Round | 29/08/2021 | Torpedo Moskva | - | Metallurg Lipetsk | 7:1 | ||||
| 12. Round | 19/09/2021 | Alania Vladikavkaz | - | Metallurg Lipetsk | 5:0 | ||||
| 18. Round | 17/10/2021 | Metallurg Lipetsk | - | Baltika Kaliningrad | 0:4 | |
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| 24. Round | 21/11/2021 | Metallurg Lipetsk | - | FK Kamaz | 0:1 | |
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| 25. Round | 27/11/2021 | FK Krasnodar 2 | - | Metallurg Lipetsk | 1:0 |
Russia