| 1. Round | 25/07/2021 | Zenit St. Petersburg [Youth] | - | Kuban Krasnodar [Youth] | 2:3 |  |
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| 2. Round | 31/07/2021 | Zenit St. Petersburg [Youth] | - | FK Krasnodar [Youth] | 2:3 |  |
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| 3. Round | 07/08/2021 | FK Saturn [Youth] | - | Zenit St. Petersburg [Youth] | 1:2 | |
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| 4. Round | 14/08/2021 | Spartak Moskva [Youth] | - | Zenit St. Petersburg [Youth] | 1:1 | ||||
| 8. Round | 19/09/2021 | Zenit St. Petersburg [Youth] | - | FK Strogino Moskva [Youth] | 4:2 | |
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| 9. Round | 25/09/2021 | Chertanovo Football Academy [Youth] | - | Zenit St. Petersburg [Youth] | 3:2 | |
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| 10. Round | 02/10/2021 | Zenit St. Petersburg [Youth] | - | FK Rostov [Youth] | 2:1 | |
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| 11. Round | 16/10/2021 | SShOR Zenit [Youth] | - | Zenit St. Petersburg [Youth] | 1:1 | ||||
| 12. Round | 23/10/2021 | FShM Moskva [Youth] | - | Zenit St. Petersburg [Youth] | 1:4 |
Russia