| 3. Round | 25/07/2010 | Shakhtar Donetsk | - | Zorya Lugansk | 1:0 |  |
|||
| 4. Round | 30/07/2010 | Arsenal Kiev | - | Shakhtar Donetsk | 1:3 |  |
|||
| 5. Round | 07/08/2010 | Shakhtar Donetsk | - | PFK Sevastopol | 5:0 | ||||
| 6. Round | 15/08/2010 | Shakhtar Donetsk | - | Karpaty Lviv | 1:0 | ||||
| 7. Round | 21/08/2010 | Volyn Lutsk | - | Shakhtar Donetsk | 0:1 | ||||
| 8. Round | 29/08/2010 | Shakhtar Donetsk | - | FK Illichivets | 1:0 | ||||
| 13. Round | 15/10/2010 | Metalurh Donetsk | - | Shakhtar Donetsk | 0:2 | |
|||
| 14. Round | 23/10/2010 | Shakhtar Donetsk | - | Vorskla Poltava | 1:0 | ||||
| 15. Round | 30/10/2010 | Dnipro Dnipropetrovsk | - | Shakhtar Donetsk | 0:1 | ||||
| 16. Round | 06/11/2010 | FK Krivbas (old) | - | Shakhtar Donetsk | 0:2 | |
|||
| 17. Round | 13/11/2010 | Shakhtar Donetsk | - | Metalurg Zaporizhya | 2:1 | ||||
| 18. Round | 20/11/2010 | Zorya Lugansk | - | Shakhtar Donetsk | 1:3 | ||||
| 19. Round | 28/11/2010 | Shakhtar Donetsk | - | Arsenal Kiev | 4:0 | ||||
| 20. Round | 03/03/2011 | PFK Sevastopol | - | Shakhtar Donetsk | 0:1 | ||||
| 21. Round | 13/03/2011 | Karpaty Lviv | - | Shakhtar Donetsk | 1:0 | ||||
| 22. Round | 20/03/2011 | Shakhtar Donetsk | - | Volyn Lutsk | 4:0 |
Ukraine