| 1. Round | 10/07/2021 | Spartak Moskva 2 | - | FK Krasnodar 2 | 0:0 | ||||
| 2. Round | 17/07/2021 | FK Krasnodar 2 | - | Alania Vladikavkaz | 1:3 |  |
|||
| 4. Round | 31/07/2021 | FK Krasnodar 2 | - | Olimp-Dolgoprudny | 2:0 | ||||
| 5. Round | 08/08/2021 | SKA-Khabarovsk | - | FK Krasnodar 2 | 1:0 | ||||
| 6. Round | 14/08/2021 | FK Krasnodar 2 | - | Volgar Astrakhan | 1:0 | ||||
| 7. Round | 21/08/2021 | Metallurg Lipetsk | - | FK Krasnodar 2 | 1:2 | ||||
| 8. Round | 29/08/2021 | Baltika Kaliningrad | - | FK Krasnodar 2 | 2:1 | ||||
| 9. Round | 05/09/2021 | Fakel Voronezh | - | FK Krasnodar 2 | 0:0 | ||||
| 10. Round | 11/09/2021 | FK Krasnodar 2 | - | FK Tom Tomsk | 2:1 |  |
|||
| 11. Round | 15/09/2021 | FK Orenburg | - | FK Krasnodar 2 | 2:0 | ||||
| 12. Round | 19/09/2021 | FK Krasnodar 2 | - | Akron Tolyatti | 2:0 | |
|||
| 13. Round | 25/09/2021 | FK Neftekhimik | - | FK Krasnodar 2 | 4:1 | ||||
| 15. Round | 03/10/2021 | FK Kamaz | - | FK Krasnodar 2 | 2:0 | ||||
| 19. Round | 23/10/2021 | FK Krasnodar 2 | - | Kuban Krasnodar | 1:2 | ||||
| 20. Round | 31/10/2021 | Alania Vladikavkaz | - | FK Krasnodar 2 | 2:1 | ||||
| 21. Round | 06/11/2021 | Tekstilshchik Ivanovo | - | FK Krasnodar 2 | 0:1 | ||||
| 22. Round | 13/11/2021 | Olimp-Dolgoprudny | - | FK Krasnodar 2 | 0:1 |
Russia