| 1. Round | 24/07/2021 | FK Yessentuki | - | FK Biolog Novokubansk | 0:5 | ||||
| 3. Round | 07/08/2021 | FK Biolog Novokubansk | - | FK Legion Dynamo Makhachkala | 0:0 | ||||
| 4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | ||||
| 5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 |  |
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| 6. Round | 29/08/2021 | FK Chayka | - | FK Biolog Novokubansk | 2:1 |  |
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| 7. Round | 04/09/2021 | FK Biolog Novokubansk | - | Anzhi Makhachkala | 0:2 | ||||
| 8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 | |
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| 9. Round | 12/09/2021 | FK Biolog Novokubansk | - | Alania-2 Vladikavkaz | 5:3 | ||||
| 13. Round | 10/10/2021 | FK Biolog Novokubansk | - | Rotor-2 Volgograd | 3:0 |
Russia
Germany