| 4. Round | 13/08/2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 5. Round | 20/08/2021 | Vorskla Poltava | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 9. Round | 26/09/2021 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 |  |
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| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 15. Round | 22/11/2021 | NK Veres | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 |
Ukraine