| 1. Round | 23/07/2021 | FK Lviv | - | FK Mariupol | 1:1 | ||||
| 2. Round | 01/08/2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 3. Round | 07/08/2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Round | 16/08/2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | ||||
| 5. Round | 22/08/2021 | FK Mariupol | - | Zorya Lugansk | 3:4 | ||||
| 6. Round | 28/08/2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Round | 12/09/2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 |  |
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| 9. Round | 25/09/2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 10. Round | 01/10/2021 | FK Mariupol | - | Rukh Lviv | 0:2 |  |
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| 11. Round | 16/10/2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Round | 23/10/2021 | NK Veres | - | FK Mariupol | 2:0 | ||||
| 13. Round | 30/10/2021 | FK Mariupol | - | Dinamo Kiev | 2:3 | ||||
| 14. Round | 06/11/2021 | FC Mynai | - | FK Mariupol | 0:2 | ||||
| 15. Round | 21/11/2021 | Vorskla Poltava | - | FK Mariupol | 5:1 | |
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| 16. Round | 26/11/2021 | FK Mariupol | - | FK Lviv | 0:1 | ||||
| 17. Round | 05/12/2021 | Desna Chernigov | - | FK Mariupol | 3:3 | ||||
| 18. Round | 10/12/2021 | FK Mariupol | - | SK Dnipro-1 | 0:3 |
Ukraine