| 1. Round | 17/03/2018 | Charlotte Independence | - | Ottawa Fury | 4:1 | ||||
| 1. Round | 24/03/2018 | Charlotte Independence | - | Toronto FC 2 | 2:0 | ||||
| 2. Round | 15/04/2018 | Charlotte Independence | - | North Carolina FC | 0:2 |  |
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| 4. Round | 17/06/2018 | Charlotte Independence | - | Charleston Battery | 1:1 | ||||
| 4. Round | 28/06/2018 | Charlotte Independence | - | Tampa Bay Rowdies | 2:2 |  |
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| 5. Round | 19/07/2018 | FC Cincinnati | - | Charlotte Independence | 2:0 | ||||
| 8. Round | 14/10/2018 | Charlotte Independence | - | North Carolina FC | 1:3 |
USA