| 3. Round | 26/04/2021 | Puerto Montt | - | San Luis | 2:1 | ||||
| 5. Round | 09/05/2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 11. Round | 15/07/2021 | Santiago Morning | - | San Luis | 0:0 | ||||
| 13. Round | 01/08/2021 | Coquimbo Unido | - | San Luis | 0:1 | ||||
| 14. Round | 10/08/2021 | San Luis | - | CD Magallanes | 1:1 |  |
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| 15. Round | 17/08/2021 | Barnechea | - | San Luis | 0:0 | ||||
| 16. Round | 23/08/2021 | San Luis | - | Deportes Temuco | 1:1 |  |
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| 17. Round | 28/08/2021 | Rangers | - | San Luis | 0:1 | ||||
| 18. Round | 01/09/2021 | San Luis | - | Puerto Montt | 0:1 | ||||
| 19. Round | 07/09/2021 | Unión San Felipe | - | San Luis | 1:1 |  |
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| 21. Round | 22/09/2021 | Fernández Vial | - | San Luis | 2:2 | ||||
| 22. Round | 26/09/2021 | Deportes Copiapó | - | San Luis | 4:1 | ||||
| 23. Round | 02/10/2021 | San Luis | - | Cobreloa | 1:0 | ||||
| 30. Round | 12/11/2021 | San Luis | - | Barnechea | 2:1 |
Chile