| 9. Round | 22/10/2016 | Fénix | - | Boston River | 1:1 |  |
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| 10. Round | 29/10/2016 | Boston River | - | Danubio | 1:2 | ||||
| 11. Round | 13/11/2016 | Plaza Colonia | - | Boston River | 2:2 |  |
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| 12. Round | 19/11/2016 | Villa Española | - | Boston River | 0:3 | ||||
| 13. Round | 28/11/2016 | Boston River | - | Liverpool | 0:0 | ||||
| 14. Round | 03/12/2016 | Boston River | - | Rampla Juniors | 2:0 | ||||
| 15. Round | 11/12/2016 | Nacional | - | Boston River | 1:0 |
Brazil