| 6. Round | 05/09/2021 | San Diego Loyal | - | Los Angeles Galaxy II | 4:2 | ||||
| 6. Round | 12/09/2021 | Oakland Roots | - | San Diego Loyal | 0:0 |  |
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| 6. Round | 19/09/2021 | San Diego Loyal | - | Tacoma Defiance | 1:0 | ||||
| 6. Round | 23/09/2021 | Oakland Roots | - | San Diego Loyal | 2:1 | ||||
| 6. Round | 26/09/2021 | Las Vegas Lights FC | - | San Diego Loyal | 2:4 | ||||
| 7. Round | 10/10/2021 | San Diego Loyal | - | Sacramento Republic | 2:1 |  |
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| 7. Round | 17/10/2021 | San Diego Loyal | - | New Mexico United | 1:1 | |
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| 7. Round | 21/10/2021 | Orange County SC | - | San Diego Loyal | 1:0 | ||||
| 7. Round | 24/10/2021 | San Diego Loyal | - | Oakland Roots | 3:4 | ||||
| 7. Round | 31/10/2021 | Sacramento Republic | - | San Diego Loyal | 1:1 |
Honduras