| 1. Round | 12/09/2020 | sc Heerenveen | - | Willem II | 2:0 | ||||
| 2. Round | 20/09/2020 | Willem II | - | Heracles Almelo | 4:0 | ||||
| 3. Round | 27/09/2020 | FC Emmen | - | Willem II | 1:1 | ||||
| 4. Round | 04/10/2020 | Willem II | - | Feyenoord | 1:4 | ||||
| 5. Round | 17/10/2020 | Willem II | - | FC Twente | 0:3 | ||||
| 15. Round | 10/01/2021 | VVV-Venlo | - | Willem II | 2:1 | ||||
| 16. Round | 14/01/2021 | Willem II | - | FC Groningen | 2:3 | ||||
| 28. Round | 03/04/2021 | Willem II | - | AZ Alkmaar | 0:1 |  |
|||
| 29. Round | 10/04/2021 | Heracles Almelo | - | Willem II | 4:0 | ||||
| 30. Round | 23/04/2021 | Willem II | - | RKC Waalwijk | 1:0 | ||||
| 31. Round | 01/05/2021 | FC Utrecht | - | Willem II | 3:2 | ||||
| 32. Round | 09/05/2021 | Willem II | - | PSV Eindhoven | 0:2 | ||||
| 33. Round | 13/05/2021 | ADO Den Haag | - | Willem II | 1:4 | ||||
| 34. Round | 16/05/2021 | Willem II | - | Fortuna Sittard | 2:1 |
Netherlands