| 27. Round | 29/08/2024 | Philadelphia Union | - | Columbus Crew | 0:1 | ||||
| 28. Round | 01/09/2024 | Columbus Crew | - | New York City FC | 4:2 | ||||
| 17. Round | 08/09/2024 | Columbus Crew | - | Seattle Sounders | 0:4 | ||||
| 30. Round | 19/09/2024 | Toronto FC | - | Columbus Crew | 0:2 | ||||
| 31. Round | 22/09/2024 | Columbus Crew | - | Orlando City | 4:3 | ||||
| 32. Round | 29/09/2024 | D.C. United | - | Columbus Crew | 2:2 | ||||
| 33. Round | 03/10/2024 | Columbus Crew | - | Inter Miami CF | 2:3 | ||||
| 34. Round | 06/10/2024 | Columbus Crew | - | Philadelphia Union | 3:2 | ||||
| 16. Round | 13/10/2024 | Columbus Crew | - | New England Revolution | 4:0 | ||||
| 35. Round | 19/10/2024 | New York RB | - | Columbus Crew | 2:3 |
France