| 1. Round | 24/07/2021 | Dinamo Stavropol | - | FK Mashuk KMV | 1:1 |  |
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| 3. Round | 06/08/2021 | FK Yessentuki | - | FK Mashuk KMV | 0:2 | |
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| 4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | |
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| 5. Round | 20/08/2021 | FK Legion Dynamo Makhachkala | - | FK Mashuk KMV | 2:2 | |
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| 7. Round | 04/09/2021 | FK Mashuk KMV | - | Spartak Nalchik | 1:2 | |
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| 8. Round | 08/09/2021 | FK Chayka | - | FK Mashuk KMV | 3:0 | ||||
| 9. Round | 13/09/2021 | FK Mashuk KMV | - | Anzhi Makhachkala | 0:3 | ||||
| 10. Round | 18/09/2021 | FK Druzhba | - | FK Mashuk KMV | 1:1 | |
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| 11. Round | 26/09/2021 | FK Mashuk KMV | - | Alania-2 Vladikavkaz | 4:1 | |
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| 12. Round | 03/10/2021 | Kuban-Holding Pavlovskaya | - | FK Mashuk KMV | 1:0 | ||||
| 13. Round | 10/10/2021 | FK Mashuk KMV | - | Forte Taganrog | 0:2 | |
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| 14. Round | 17/10/2021 | FK Dinamo Makhachkala | - | FK Mashuk KMV | 2:1 | ||||
| 15. Round | 23/10/2021 | FK Mashuk KMV | - | Rotor-2 Volgograd | 1:1 | |
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| 19. Round | 27/10/2021 | FK Mashuk KMV | - | FK Yessentuki | 7:0 | |
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| 16. Round | 01/11/2021 | FK Tuapse | - | FK Mashuk KMV | 3:0 | ||||
| 17. Round | 06/11/2021 | FK Mashuk KMV | - | FK SKA Rostov | 0:2 | |
Russia