| 1. Round | 16/04/2022 | Manta FC [U19] | - | Atlético Santo Domingo [U19] | 0:1 | ||||
| 2. Round | 23/04/2022 | 9 de Octubre [U19] | - | Atlético Santo Domingo [U19] | 4:2 | ||||
| 3. Round | 07/05/2022 | Atlético Santo Domingo [U19] | - | Delfín SC [U19] | 0:0 | ||||
| 5. Round | 28/05/2022 | Atlético Santo Domingo [U19] | - | Guayaquil City [U19] | 0:1 | ||||
| 6. Round | 04/06/2022 | Atlético Santo Domingo [U19] | - | Manta FC [U19] | 3:1 | ||||
| 10. Round | 05/08/2022 | Guayaquil City [U19] | - | Atlético Santo Domingo [U19] | 0:1 |  |
Ecuador