| 1. Round | 13/03/2022 | Sepsi OSK | - | CS Mioveni | 3:1 | ||||
| 2. Round | 20/03/2022 | Dinamo Bucureşti | - | Sepsi OSK | 0:0 | ||||
| 3. Round | 04/04/2022 | Sepsi OSK | - | Academica Clinceni | 6:0 | ||||
| 4. Round | 10/04/2022 | FC Botoşani | - | Sepsi OSK | 0:1 | ||||
| 5. Round | 16/04/2022 | Sepsi OSK | - | UTA Arad | 1:0 | ||||
| 7. Round | 29/04/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 3:1 |  |
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| 9. Round | 16/05/2022 | FC Universitatea Craiova | - | Sepsi OSK | 0:5 |
Spain