1. Round | 27/07/2008 | CF América | - | Santos Laguna | 3:2 | ||||
2. Round | 03/08/2008 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
3. Round | 10/08/2008 | Puebla FC | - | Santos Laguna | 0:0 | ||||
4. Round | 18/08/2008 | Santos Laguna | - | Indios Juárez | 3:0 | ||||
5. Round | 24/08/2008 | Deportivo Guadalajara | - | Santos Laguna | 3:5 | ||||
6. Round | 27/08/2008 | Santos Laguna | - | UAG Tecos | 2:0 | ||||
7. Round | 30/08/2008 | CF Monterrey | - | Santos Laguna | 2:0 | ||||
8. Round | 14/09/2008 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
9. Round | 20/09/2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
10. Round | 28/09/2008 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
11. Round | 05/10/2008 | Santos Laguna | - | Monarcas Morelia | 1:0 | ||||
12. Round | 12/10/2008 | CF Pachuca | - | Santos Laguna | 2:0 | ||||
13. Round | 20/10/2008 | Santos Laguna | - | Jaguares Chiapas | 1:0 | ||||
14. Round | 26/10/2008 | Atlas Guadalajara | - | Santos Laguna | 2:1 | ||||
15. Round | 02/11/2008 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
16. Round | 08/11/2008 | Club San Luis | - | Santos Laguna | 2:2 | ||||
17. Round | 16/11/2008 | Santos Laguna | - | Atlante | 0:0 |