| 4. Round | 10/10/2021 | Yalmakan FC | - | Deportivo Dongu | 0:1 | ||||
| 5. Round | 13/10/2021 | Deportivo Dongu | - | Lobos ULMX | 2:2 |  |
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| 6. Round | 17/10/2021 | Reboceros de La Piedad | - | Deportivo Dongu | 2:2 | ||||
| 7. Round | 22/10/2021 | Inter Playa | - | Deportivo Dongu | 1:0 | ||||
| 8. Round | 30/10/2021 | Deportivo Dongu | - | Cañoneros FC | 1:0 | ||||
| 10. Round | 10/11/2021 | Deportivo Dongu | - | Escorpiones | 2:1 | |
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| 11. Round | 14/11/2021 | Cafetaleros de Chiapas | - | Deportivo Dongu | 4:0 | ||||
| 12. Round | 20/11/2021 | Deportivo Dongu | - | CD Zap | 0:2 | ||||
| 13. Round | 27/11/2021 | Inter de Querétaro | - | Deportivo Dongu | 3:0 |
Mexico