| 1. Round | 06/01/2019 | Lobos BUAP [U17] | - | Santos Laguna [U17] | 0:2 | ||||
| 2. Round | 13/01/2019 | Santos Laguna [U17] | - | Monarcas Morelia [U17] | 1:1 | ||||
| 3. Round | 18/01/2019 | Puebla FC [U17] | - | Santos Laguna [U17] | 0:2 |  |
|||
| 4. Round | 27/01/2019 | Santos Laguna [U17] | - | Deportivo Guadalajara [U17] | 1:0 | ||||
| 5. Round | 02/02/2019 | UANL Tigres [U17] | - | Santos Laguna [U17] | 0:1 | ||||
| 6. Round | 10/02/2019 | Santos Laguna [U17] | - | Club Tijuana [U17] | 1:0 | ||||
| 7. Round | 16/02/2019 | Cruz Azul [U17] | - | Santos Laguna [U17] | 0:8 |  |
|||
| 8. Round | 24/02/2019 | Santos Laguna [U17] | - | Deportivo Toluca [U17] | 2:1 | ||||
| 9. Round | 02/03/2019 | Club León [U17] | - | Santos Laguna [U17] | 1:0 | |
|||
| 10. Round | 08/03/2019 | CD Veracruz [U17] | - | Santos Laguna [U17] | 1:0 | ||||
| 13. Round | 07/04/2019 | Santos Laguna [U17] | - | CF Pachuca [U17] | 3:1 | ||||
| 15. Round | 10/04/2019 | Santos Laguna [U17] | - | Gallos Blancos [U17] | 2:1 | ||||
| 16. Round | 27/04/2019 | CF América [U17] | - | Santos Laguna [U17] | 2:1 | |
|||
| 17. Round | 05/05/2019 | Santos Laguna [U17] | - | Pumas UNAM [U17] | 1:1 |
Mexico