| 4. Round | 10/10/2021 | Colima FC | - | Leones Negros II | 2:1 | ||||
| 5. Round | 13/10/2021 | Correcaminos UAT II | - | Leones Negros II | 1:1 |  |
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| 6. Round | 16/10/2021 | Leones Negros II | - | Coras de Nayarit | 2:0 | ||||
| 7. Round | 23/10/2021 | Mineros de Fresnillo FC | - | Leones Negros II | 0:3 | ||||
| 8. Round | 30/10/2021 | Leones Negros II | - | Tuzos de la UAZ | 1:0 | |
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| 9. Round | 06/11/2021 | Alacranes de Durango | - | Leones Negros II | 2:1 |
Mexico