| 4. Round | 29/01/2025 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 5. Round | 01/02/2025 | Mazatlán FC | - | Club León | 1:2 |  |
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| 1. Round | 06/02/2025 | CF Pachuca | - | Club León | 1:2 | ||||
| 6. Round | 09/02/2025 | Club León | - | Deportivo Toluca | 3:3 | ||||
| 11. Round | 09/03/2025 | Santos Laguna | - | Club León | 2:1 | ||||
| 13. Round | 31/03/2025 | Club León | - | Pumas UNAM | 1:2 | ||||
| 17. Round | 21/04/2025 | Club León | - | CF Monterrey | 0:2 |
Colombia