| 1. Round | 02/07/2022 | Club Necaxa | - | Deportivo Toluca | 1:3 |  |
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| 2. Round | 10/07/2022 | Gallos Blancos | - | Club Necaxa | 1:2 | ||||
| 3. Round | 17/07/2022 | Pumas UNAM | - | Club Necaxa | 1:0 | ||||
| 4. Round | 23/07/2022 | Club Necaxa | - | FC Juárez | 1:0 |  |
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| 6. Round | 30/07/2022 | Cruz Azul | - | Club Necaxa | 1:0 | ||||
| 15. Round | 19/09/2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 16. Round | 24/09/2022 | Club Necaxa | - | Mazatlán FC | 2:2 | |
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| 17. Round | 02/10/2022 | Atlas Guadalajara | - | Club Necaxa | 1:0 |
Spain