| 3. Round | 29/01/2022 | Mazorqueros | - | Coras de Nayarit | 1:1 | ||||
| 4. Round | 05/02/2022 | Mineros de Fresnillo FC | - | Mazorqueros | 1:3 | ||||
| 6. Round | 19/02/2022 | Alacranes de Durango | - | Mazorqueros | 1:1 |  |
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| 8. Round | 05/03/2022 | Saltillo FC | - | Mazorqueros | 1:5 | ||||
| 9. Round | 12/03/2022 | Mazorqueros | - | Tritones Vallarta | 1:0 | ||||
| 11. Round | 26/03/2022 | Mazorqueros | - | Gavilanes de Matamoros | 0:0 | ||||
| 12. Round | 02/04/2022 | Mazorqueros | - | Correcaminos UAT II | 5:1 | ||||
| 13. Round | 09/04/2022 | Tecos Fútbol Club | - | Mazorqueros | 2:2 |
Mexico