| 4. Round | 13/08/2020 | CF América [U17] | - | Santos Laguna [U17] | 3:1 | ||||
| 8. Round | 04/09/2020 | FC Juárez [U17] | - | Santos Laguna [U17] | 0:0 | ||||
| 9. Round | 09/09/2020 | Santos Laguna [U17] | - | Pumas UNAM [U17] | 5:1 | ||||
| 11. Round | 20/09/2020 | Deportivo Toluca [U17] | - | Santos Laguna [U17] | 4:2 |  |
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| 12. Round | 27/09/2020 | Santos Laguna [U17] | - | Club Tijuana [U17] | 0:3 | ||||
| 1. Round | 10/10/2020 | Cruz Azul [U17] | - | Santos Laguna [U17] | 1:1 | ||||
| 16. Round | 02/11/2020 | Club León [U17] | - | Santos Laguna [U17] | 0:1 | ||||
| 2. Round | 13/11/2020 | Santos Laguna [U17] | - | Deportivo Guadalajara [U17] | 0:3 |
Mexico