| 1. Round | 01/07/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 0:2 | ||||
| 2. Round | 08/07/2022 | Mazatlán FC [U20] | - | UANL Tigres [U20] | 1:3 | ||||
| 3. Round | 18/07/2022 | CF Pachuca [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 4. Round | 22/07/2022 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 5:0 | ||||
| 5. Round | 27/07/2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 5:0 | ||||
| 6. Round | 30/07/2022 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:1 |  |
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| 7. Round | 05/08/2022 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 9. Round | 16/08/2022 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 0:1 | ||||
| 10. Round | 19/08/2022 | FC Juárez [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 11. Round | 26/08/2022 | Mazatlán FC [U20] | - | CF América [U20] | 4:4 | ||||
| 12. Round | 03/09/2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 14. Round | 11/09/2022 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 15. Round | 16/09/2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 13. Round | 20/09/2022 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 4:0 |
Mexico