2. Round | 27/07/2021 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
4. Round | 07/08/2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
5. Round | 14/08/2021 | Club Olimpia | - | Cerro Porteño | 0:3 | ||||
7. Round | 28/08/2021 | Club Olimpia | - | Sol de América | 0:1 | ||||
8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | ||||
9. Round | 21/09/2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
12. Round | 18/10/2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
14. Round | 31/10/2021 | Cerro Porteño | - | Club Olimpia | 1:0 |