1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
2. Round | 12/02/2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
4. Round | 26/03/2022 | Sol de América | - | Club Olimpia | 0:1 | ||||
8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
22. Round | 03/07/2022 | Guaraní | - | Club Olimpia | 0:2 |