| 12. Round | 21/11/2021 | RFCU Luxemburg | - | FC Differdange 03 | 3:1 |  |
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| 13. Round | 28/11/2021 | FC Differdange 03 | - | Union Titus Pétange | 4:0 | ||||
| 15. Round | 12/12/2021 | FC Differdange 03 | - | Etzella Ettelbruck | 4:0 | ||||
| 16. Round | 06/02/2022 | FC Differdange 03 | - | Victoria Rosport | 4:0 | ||||
| 17. Round | 13/02/2022 | CS FOLA Esch | - | FC Differdange 03 | 2:4 | ||||
| 18. Round | 20/02/2022 | FC Differdange 03 | - | UNA Strassen | 2:1 |
Luxembourg