| 1. Round | 20/07/2021 | Once Caldas | - | Atlético Huila | 1:0 | ||||
| 2. Round | 24/07/2021 | Atlético Huila | - | Patriotas FC | 2:2 | ||||
| 3. Round | 02/08/2021 | Jaguares de Córdoba | - | Atlético Huila | 2:0 |  |
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| 4. Round | 07/08/2021 | Atlético Huila | - | Deportes Quindío | 0:0 | ||||
| 5. Round | 16/08/2021 | Atlético Huila | - | Águilas Doradas | 0:2 | ||||
| 6. Round | 24/08/2021 | Atlético Bucaramanga | - | Atlético Huila | 1:1 | ||||
| 7. Round | 29/08/2021 | Atlético Huila | - | Independiente Medellín | 3:1 | ||||
| 9. Round | 14/09/2021 | Atlético Huila | - | Deportes Tolima | 1:2 | ||||
| 10. Round | 19/09/2021 | Millonarios | - | Atlético Huila | 3:1 | ||||
| 13. Round | 10/10/2021 | Atlético Huila | - | Atlético Nacional | 1:4 | |
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| 14. Round | 16/10/2021 | Deportes Tolima | - | Atlético Huila | 1:0 | ||||
| 15. Round | 25/10/2021 | Atlético Huila | - | Santa Fe | 1:2 | ||||
| 16. Round | 28/10/2021 | Deportivo Pasto | - | Atlético Huila | 1:0 |
Colombia