| 1. Round | 21/07/2018 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 2:0 | ||||
| 2. Round | 28/07/2018 | Deportivo Guadalajara [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 4. Round | 12/08/2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 8. Round | 01/09/2018 | Deportivo Guadalajara [U20] | - | CF Pachuca [U20] | 2:2 | ||||
| 9. Round | 15/09/2018 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 2:0 |  |
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| 10. Round | 23/09/2018 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 5:1 | ||||
| 11. Round | 30/09/2018 | CF América [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 12. Round | 05/10/2018 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 2:0 |  |
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| 14. Round | 27/10/2018 | Deportivo Guadalajara [U20] | - | Monarcas Morelia [U20] | 2:1 | ||||
| 15. Round | 02/11/2018 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 16. Round | 10/11/2018 | Club León [U20] | - | Deportivo Guadalajara [U20] | 2:0 | ||||
| 17. Round | 24/11/2018 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 3:2 |
Mexico