| 1. Round | 18/07/2021 | FK Leningradets | - | FK Kairat Moskva | 2:2 |  |
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| 2. Round | 23/07/2021 | FK Krasava | - | FK Leningradets | 1:1 |  |
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| 3. Round | 01/08/2021 | FK Leningradets | - | FK Chita | 2:1 | ||||
| 4. Round | 07/08/2021 | FK Tver | - | FK Leningradets | 3:0 | ||||
| 7. Round | 30/08/2021 | Baltika Kaliningrad 2 | - | FK Leningradets | 0:1 | ||||
| 8. Round | 04/09/2021 | FK Leningradets | - | Luki-Energiya Velikiye Luki | 6:0 | ||||
| 9. Round | 10/09/2021 | Zenit St. Petersburg 2 | - | FK Leningradets | 1:1 | ||||
| 13. Round | 30/09/2021 | FK Chita | - | FK Leningradets | 2:2 | ||||
| 14. Round | 04/10/2021 | FK Leningradets | - | FK Tver | 6:1 | ||||
| 17. Round | 19/10/2021 | FK Leningradets | - | Baltika Kaliningrad 2 | 2:0 | ||||
| 18. Round | 25/10/2021 | Luki-Energiya Velikiye Luki | - | FK Leningradets | 0:1 | ||||
| 19. Round | 31/10/2021 | FK Leningradets | - | Zenit St. Petersburg 2 | 7:1 | ||||
| 20. Round | 04/11/2021 | Zvezda St. Petersburg | - | FK Leningradets | 0:1 | |
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| 21. Round | 10/11/2021 | FK Leningradets | - | Dinamo St. Petersburg | 0:1 | ||||
| 22. Round | 14/11/2021 | FK Kairat Moskva | - | FK Leningradets | 2:3 | |
Russia