| 1. Round | 19/07/2001 | Deportivo Toluca | - | Club León | 3:1 |  |
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| 2. Round | 27/07/2001 | Club León | - | CF Monterrey | 1:0 | |
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| 3. Round | 02/08/2001 | Atletico Celaya | - | Club León | 2:1 | |
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| 4. Round | 10/08/2001 | Club León | - | Deportivo Guadalajara | 1:2 | |
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| 5. Round | 14/08/2001 | UAG Tecos | - | Club León | 2:1 | |
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| 8. Round | 07/09/2001 | Club León | - | Monarcas Morelia | 1:1 | ||||
| 10. Round | 21/09/2001 | Club León | - | CF Pachuca | 1:1 | ||||
| 11. Round | 27/09/2001 | UANL Tigres | - | Club León | 1:0 | ||||
| 12. Round | 05/10/2001 | Club León | - | Club Irapuato | 2:2 | |
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| 13. Round | 11/10/2001 | Atlas Guadalajara | - | Club León | 4:1 | ||||
| 16. Round | 02/11/2001 | Club León | - | Cruz Azul | 2:2 | |
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| 18. Round | 16/11/2001 | Puebla FC | - | Club León | 2:2 |  |
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Chile