| 1. Round | 12/02/2021 | San Lorenzo II | - | Arsenal de Sarandí II | 3:0 | ||||
| 3. Round | 26/02/2021 | San Lorenzo II | - | Central Córdoba SdE II | 2:1 | ||||
| 4. Round | 05/03/2021 | San Lorenzo II | - | Huracán II | 2:2 | ||||
| 5. Round | 12/03/2021 | Banfield II | - | San Lorenzo II | 2:1 | ||||
| 6. Round | 19/03/2021 | San Lorenzo II | - | Aldosivi II | 0:1 | ||||
| 9. Round | 09/04/2021 | Platense II | - | San Lorenzo II | 2:0 | ||||
| 10. Round | 16/04/2021 | San Lorenzo II | - | Argentinos Juniors II | 2:2 | ||||
| 11. Round | 23/04/2021 | River Plate II | - | San Lorenzo II | 2:1 | ||||
| 12. Round | 30/04/2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 13. Round | 07/05/2021 | Racing Club II | - | San Lorenzo II | 1:2 |
Argentina