| 3. Round | 04/10/2020 | Club Irapuato | - | Deportivo Dongu | 2:0 | ||||
| 4. Round | 10/10/2020 | Aguacateros CDU | - | Club Irapuato | 0:4 | ||||
| 5. Round | 17/10/2020 | Club Irapuato | - | Pioneros de Cancún | 4:1 | ||||
| 6. Round | 25/10/2020 | Cafessa Jalisco | - | Club Irapuato | 4:3 | ||||
| 11. Round | 27/11/2020 | Inter Playa | - | Club Irapuato | 2:0 | ||||
| 7. Round | 02/12/2020 | Club Irapuato | - | Cafetaleros de Chiapas | 4:2 | ||||
| 12. Round | 06/12/2020 | Club Irapuato | - | Club de Ciervos | 0:0 | ||||
| 13. Round | 11/12/2020 | Cañoneros Marina | - | Club Irapuato | 1:2 | ||||
| 1. Round | 16/12/2020 | Club Irapuato | - | Cruz Azul Hidalgo | 0:2 | ||||
| 16. Round | 30/01/2021 | Deportivo Dongu | - | Club Irapuato | 0:7 |  |
Mexico