| 4. Round | 05/02/2022 | Cafetaleros de Chiapas | - | Inter de Querétaro | 4:0 | ||||
| 5. Round | 12/02/2022 | Inter de Querétaro | - | CD Zap | 0:3 | ||||
| 6. Round | 18/02/2022 | Inter Playa | - | Inter de Querétaro | 3:0 | ||||
| 7. Round | 27/02/2022 | Montañeses FC | - | Inter de Querétaro | 1:2 | ||||
| 9. Round | 12/03/2022 | Sporting Canamy | - | Inter de Querétaro | 2:0 | ||||
| 11. Round | 27/03/2022 | Lobos ULMX | - | Inter de Querétaro | 0:0 |
Mexico