| 4. Round | 22/09/2010 | US Lecce | - | Parma FC | 1:1 | ||||
| 7. Round | 17/10/2010 | Juventus | - | US Lecce | 4:0 | ||||
| 8. Round | 24/10/2010 | US Lecce | - | Brescia Calcio | 2:1 |  |
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| 9. Round | 30/10/2010 | AS Roma | - | US Lecce | 2:0 |  |
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| 11. Round | 10/11/2010 | US Lecce | - | Inter | 1:1 | ||||
| 14. Round | 28/11/2010 | Cagliari Calcio | - | US Lecce | 3:2 | ||||
| 15. Round | 05/12/2010 | US Lecce | - | Genoa CFC | 1:3 | |
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| 16. Round | 12/12/2010 | US Lecce | - | Chievo Verona | 3:2 | |
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| 17. Round | 19/12/2010 | SSC Napoli | - | US Lecce | 1:0 | ||||
| 18. Round | 06/01/2011 | US Lecce | - | AS Bari | 0:1 | ||||
| 19. Round | 09/01/2011 | Lazio Roma | - | US Lecce | 1:2 |
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