| 3. Round | 03/04/2021 | Bolívar | - | Blooming | 2:0 | ||||
| 6. Round | 04/05/2021 | Blooming | - | Club San José | 4:0 |  |
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| 7. Round | 07/05/2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
| 16. Round | 18/08/2021 | CD Guabirá | - | Blooming | 4:2 |  |
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| 17. Round | 22/08/2021 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 18. Round | 15/09/2021 | Blooming | - | Bolívar | 2:2 | |
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| 19. Round | 18/09/2021 | Club Aurora | - | Blooming | 2:0 | ||||
| 20. Round | 22/09/2021 | Blooming | - | Real Tomayapo | 0:1 | ||||
| 21. Round | 25/09/2021 | Club San José | - | Blooming | 1:2 | |
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| 22. Round | 18/10/2021 | Blooming | - | Real Santa Cruz | 3:1 | ||||
| 23. Round | 24/10/2021 | Nacional Potosí | - | Blooming | 4:0 | ||||
| 24. Round | 28/10/2021 | Blooming | - | Oriente Petrolero | 1:1 | ||||
| 25. Round | 30/10/2021 | The Strongest | - | Blooming | 2:1 | ||||
| 26. Round | 21/11/2021 | Blooming | - | Jorge Wilstermann | 2:2 | |
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| 27. Round | 27/11/2021 | Atlético Palmaflor | - | Blooming | 3:0 | ||||
| 28. Round | 01/12/2021 | Blooming | - | Always Ready | 1:2 | |
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| 29. Round | 05/12/2021 | Royal Pari | - | Blooming | 4:3 | ||||
| 30. Round | 11/12/2021 | Blooming | - | Real Potosí | 1:0 |
Bolivia