| 1. Round | 05/02/2022 | Blooming | - | Bolívar | 0:7 |  |
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| 2. Round | 12/02/2022 | Jorge Wilstermann | - | Blooming | 0:1 | ||||
| 3. Round | 19/02/2022 | Royal Pari | - | Blooming | 1:1 | ||||
| 7. Round | 02/04/2022 | Blooming | - | Always Ready | 1:0 | |
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| 9. Round | 16/04/2022 | Bolívar | - | Blooming | 6:0 | ||||
| 11. Round | 25/04/2022 | Blooming | - | Royal Pari | 1:1 | ||||
| 12. Round | 01/05/2022 | Universitario de Vinto | - | Blooming | 2:1 | |
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| 14. Round | 13/05/2022 | Blooming | - | Independiente Petrolero | 4:0 | ||||
| 15. Round | 15/05/2022 | Always Ready | - | Blooming | 3:0 | ||||
| 16. Round | 22/05/2022 | Blooming | - | Real Tomayapo | 2:1 |
Bolivia