| 1. Round | 18/02/2021 | Herrera FC | - | Independiente de La Chorrera | 0:1 | ||||
| 2. Round | 28/02/2021 | Atlético Chiriquí | - | Herrera FC | 0:2 | ||||
| 3. Round | 05/03/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:2 | ||||
| 4. Round | 14/03/2021 | Herrera FC | - | San Francisco FC | 1:0 | ||||
| 6. Round | 21/03/2021 | Herrera FC | - | Árabe Unido | 0:0 | ||||
| 7. Round | 24/03/2021 | Deportivo del Este | - | Herrera FC | 2:1 | ||||
| 9. Round | 05/04/2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | ||||
| 10. Round | 11/04/2021 | Plaza Amador | - | Herrera FC | 3:1 | ||||
| 11. Round | 18/04/2021 | Alianza | - | Herrera FC | 2:3 |  |
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| 13. Round | 25/04/2021 | Herrera FC | - | Atlético Chiriquí | 3:0 | ||||
| 15. Round | 03/05/2021 | San Francisco FC | - | Herrera FC | 0:0 |
Panama