| 2. Round | 13/03/2021 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
| 1. Round | 20/03/2021 | Club San José | - | Atlético Palmaflor | 1:3 | ||||
| 3. Round | 28/03/2021 | Nacional Potosí | - | Atlético Palmaflor | 3:2 |  |
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| 5. Round | 26/04/2021 | The Strongest | - | Atlético Palmaflor | 4:1 | ||||
| 8. Round | 11/07/2021 | Always Ready | - | Atlético Palmaflor | 3:2 |  |
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| 13. Round | 03/08/2021 | Atlético Palmaflor | - | Bolívar | 2:2 | ||||
| 14. Round | 08/08/2021 | Club Aurora | - | Atlético Palmaflor | 2:1 | ||||
| 15. Round | 14/08/2021 | Atlético Palmaflor | - | Real Tomayapo | 2:0 | ||||
| 16. Round | 18/08/2021 | Atlético Palmaflor | - | Club San José | 1:0 | ||||
| 17. Round | 23/08/2021 | Real Santa Cruz | - | Atlético Palmaflor | 1:0 | |
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| 21. Round | 28/09/2021 | Jorge Wilstermann | - | Atlético Palmaflor | 5:0 | ||||
| 24. Round | 28/10/2021 | Royal Pari | - | Atlético Palmaflor | 2:2 | ||||
| 27. Round | 27/11/2021 | Atlético Palmaflor | - | Blooming | 3:0 | |
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| 28. Round | 01/12/2021 | Bolívar | - | Atlético Palmaflor | 3:1 | |
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| 29. Round | 04/12/2021 | Atlético Palmaflor | - | Club Aurora | 3:2 | |
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| 30. Round | 11/12/2021 | Real Tomayapo | - | Atlético Palmaflor | 3:3 |
Bolivia