| 1. Round | 06/02/2022 | Independiente Petrolero | - | Always Ready | 1:2 | ||||
| 4. Round | 27/02/2022 | Bolívar | - | Always Ready | 3:0 | ||||
| 5. Round | 06/03/2022 | Always Ready | - | Jorge Wilstermann | 0:0 |  |
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| 6. Round | 12/03/2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 7. Round | 02/04/2022 | Blooming | - | Always Ready | 1:0 | |
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| 8. Round | 08/04/2022 | Always Ready | - | Universitario de Vinto | 6:2 | ||||
| 11. Round | 23/04/2022 | Real Tomayapo | - | Always Ready | 1:1 |
Bolivia