| 1. Round | 13/06/2022 | Fénix | - | Atlético San Miguel | 1:2 |  |
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| 3. Round | 25/06/2022 | Atlético San Miguel | - | Armenio | 0:0 | ||||
| 4. Round | 02/07/2022 | Dock Sud | - | Atlético San Miguel | 1:2 | |
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| 5. Round | 09/07/2022 | Atlético San Miguel | - | UAI Urquiza | 0:0 | |
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| 6. Round | 17/07/2022 | Villa San Carlos | - | Atlético San Miguel | 0:2 | ||||
| 7. Round | 23/07/2022 | Atlético San Miguel | - | Defensores Unidos de Zárate | 0:0 | ||||
| 8. Round | 31/07/2022 | Talleres (RdE) | - | Atlético San Miguel | 2:1 | ||||
| 9. Round | 05/08/2022 | Atlético San Miguel | - | Deportivo Merlo | 1:2 |  |
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| 10. Round | 14/08/2022 | Colegiales de Munro | - | Atlético San Miguel | 2:1 | ||||
| 11. Round | 20/08/2022 | Atlético San Miguel | - | Acassuso | 2:0 | ||||
| 13. Round | 03/09/2022 | Atlético San Miguel | - | Justo José de Urquiza | 3:1 | ||||
| 14. Round | 10/09/2022 | Cañuelas | - | Atlético San Miguel | 3:1 | |
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| 15. Round | 17/09/2022 | Atlético San Miguel | - | Comunicaciones de Buenos Aires | 1:1 | ||||
| 16. Round | 26/09/2022 | CA Los Andes | - | Atlético San Miguel | 0:0 | ||||
| 17. Round | 02/10/2022 | Atlético San Miguel | - | Ituzaingó | 2:0 |
Colombia