| 1. Round | 06/02/2023 | Real Santa Cruz | - | Atlético Palmaflor | 2:1 |  |
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| 2. Round | 12/02/2023 | Real Tomayapo | - | Real Santa Cruz | 1:0 |  |
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| 4. Round | 25/02/2023 | Real Santa Cruz | - | CD Guabirá | 0:0 | |
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| 5. Round | 04/03/2023 | Royal Pari | - | Real Santa Cruz | 1:1 | |
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| 6. Round | 11/03/2023 | Real Santa Cruz | - | The Strongest | 1:1 | |
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| 8. Round | 09/04/2023 | Real Santa Cruz | - | Blooming | 2:1 | |
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| 9. Round | 17/04/2023 | Club Aurora | - | Real Santa Cruz | 1:1 | |
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| 10. Round | 23/04/2023 | Real Santa Cruz | - | Libertad Gran Mamoré | 3:2 | |
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| 11. Round | 30/04/2023 | Vaca Díez | - | Real Santa Cruz | 2:1 | |
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| 12. Round | 06/05/2023 | Real Santa Cruz | - | Always Ready | 2:1 | ||||
| 7. Round | 11/05/2023 | Oriente Petrolero | - | Real Santa Cruz | 0:1 | |
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| 14. Round | 19/05/2023 | Real Santa Cruz | - | Nacional Potosí | 2:0 |  |
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| 16. Round | 04/06/2023 | Real Santa Cruz | - | Independiente Petrolero | 1:0 | |
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| 17. Round | 25/06/2023 | Bolívar | - | Real Santa Cruz | 3:0 | |
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| 18. Round | 08/07/2023 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
| 21. Round | 30/07/2023 | CD Guabirá | - | Real Santa Cruz | 1:2 | ||||
| 24. Round | 19/08/2023 | Real Santa Cruz | - | Oriente Petrolero | 0:5 | |
Colombia