| 3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 4. Round | 13/08/2021 | Atlético San Luis | - | Club Necaxa | 0:2 | ||||
| 15. Round | 25/10/2021 | Atlético San Luis | - | Atlas Guadalajara | 2:6 | ||||
| 16. Round | 01/11/2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 17. Round | 08/11/2021 | Santos Laguna | - | Atlético San Luis | 0:0 |
Mexico