1. Round | 09/01/2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
4. Round | 30/01/2021 | Mazatlán FC | - | CF Pachuca | 1:0 | ||||
6. Round | 13/02/2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
8. Round | 27/02/2021 | Mazatlán FC | - | Gallos Blancos | 3:0 | ||||
9. Round | 04/03/2021 | Cruz Azul | - | Mazatlán FC | 1:0 | ||||
10. Round | 07/03/2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
16. Round | 24/04/2021 | Mazatlán FC | - | Club León | 4:3 |