| 13. Round | 02/03/2022 | Spartak Moskva [Youth B] | - | Chertanovo Football Academy [Youth B] | 2:0 | ||||
| 17. Round | 06/03/2022 | Zenit St. Petersburg [Youth B] | - | Spartak Moskva [Youth B] | 2:0 |  |
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| 18. Round | 12/03/2022 | FK Krasnodar [Youth B] | - | Spartak Moskva [Youth B] | 2:1 | ||||
| 20. Round | 09/04/2022 | Akademiya Konopleva [Youth B] | - | Spartak Moskva [Youth B] | 1:3 | ||||
| 14. Round | 13/04/2022 | SShOR Zenit [Youth B] | - | Spartak Moskva [Youth B] | 0:2 | ||||
| 21. Round | 17/04/2022 | Dinamo Moskva [Youth B] | - | Spartak Moskva [Youth B] | 0:4 | ||||
| 22. Round | 23/04/2022 | Spartak Moskva [Youth B] | - | CSKA Moskva [Youth B] | 0:3 | ||||
| 23. Round | 30/04/2022 | Lokomotiv Moskva [Youth B] | - | Spartak Moskva [Youth B] | 1:0 | |
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| 24. Round | 07/05/2022 | Spartak Moskva [Youth B] | - | FK Strogino Moskva [Youth B] | 1:4 | ||||
| 26. Round | 21/05/2022 | Spartak Moskva [Youth B] | - | FK Rostov [Youth B] | 0:3 |
Russia