| 1. Round | 12/09/2021 | AEK Athen | - | Ionikos Nikea | 3:0 | ||||
| 2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
| 3. Round | 22/09/2021 | AEK Athen | - | Lamia | 1:0 | ||||
| 4. Round | 26/09/2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Round | 03/10/2021 | Panetolikos | - | AEK Athen | 1:3 | ||||
| 7. Round | 24/10/2021 | Volos NFC | - | AEK Athen | 1:3 |  |
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| 9. Round | 06/11/2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 10. Round | 21/11/2021 | AEK Athen | - | Olympiakos Piraeus | 2:3 | ||||
| 12. Round | 05/12/2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 14. Round | 16/12/2021 | Ionikos Nikea | - | AEK Athen | 0:1 | ||||
| 15. Round | 20/12/2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
| 16. Round | 05/01/2022 | Lamia | - | AEK Athen | 0:2 | ||||
| 20. Round | 30/01/2022 | AEK Athen | - | Volos NFC | 1:2 | ||||
| 21. Round | 02/02/2022 | Aris Saloniki | - | AEK Athen | 2:1 |  |
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| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 23. Round | 13/02/2022 | Olympiakos Piraeus | - | AEK Athen | 1:0 | ||||
| 24. Round | 20/02/2022 | AEK Athen | - | PAS Giannina | 2:0 | |
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| 25. Round | 27/02/2022 | Panathinaikos | - | AEK Athen | 3:0 | ||||
| 26. Round | 06/03/2022 | AEK Athen | - | Asteras Tripolis | 2:1 |
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